GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2012-03 > 1330790202
From: Obed W Odom <>
Subject: Re: [DNA] New Online Tool for Haplotype Analysis (only fory-Haplogroups I1 and I2 at present)
Date: Sat, 03 Mar 2012 09:56:42 -0600
Terry, the inability to obtain a result at DYS425 is an uncommon but
well known phenomenon and is due to a
recombinational-loss-of-heterozygosity (recLOH) event between arms of a
palindrome, which prevents binding of the DYS425 forward primer (due to
a single t to c change in the primer binding site). The FTDNA advanced
test DYF371X shows what has happened. This test gives results for all 4
arms of the palindrome while the DYS425 test only gives results for 1 of
the 4 arms, the "t" arm, which usually corresponds to the second of the
4 values reported in the DYF371X test. Most I1 people have a DYF371X
result of 10c-12t-13c-14c, but my DYF371X result is 10c-10c-13c-14c.
This shows that the 12t, which would give a value of 12 in the DYS425
test, has been overwritten in my case by a copying of the 10c palindrome
arm. This loss of the "t" allele also occurs in other haplogroups, and
invariably results in no value being obtained in the DYS425 test.
On 3/3/2012 4:24 AM, Terry Robb wrote:
> You seem to have a null value reported for DYS425, so my code dropped you from the analysis. I could probably substitute in some value, but would prefer not too.
> Have you ever followed up with FTDNA about why they couldn't read your DYS425?
> On 03/03/2012, at 20:00, Obed W Odom<> wrote:
>> Terry, my kit # 85047 and Ysearch ID RQAQ2 don't seem to be recognized
>> by your program. I am I1-Z138+/Z139+ (I1f2).
>> I am a member of the Haplogroup I1 project and the I1>Z58+ and I1>Z63+
>> project.Can you check on this?
>> On 3/1/2012 10:46 PM, Terry wrote:
>>> There are common questions that people often have in regards to their
>>> 67-marker STR test results.
>>> Such as place of geographic origin, likely SNP mutations, or close
>>> haplotype matches etc.
>>> To answer such questions it helps to know where someone's 67-marker STR
>>> result fits in with everyone else's result. A rational way of organising
>>> results is to compute a hierarchical cluster tree, and then systematically
>>> label each person in that tree according to an STR "Branch Code". This
>>> Branch Code labelling system is very similar to the "Henry System" used in
>>> genealogy for numbering the known descendants of an ancestor.
>>> Easiest to see what I mean, by checking out the tool at:
>>> You can enter your FTDNA Kit Number or Ysearch ID (currently only works for
>>> haplogroups I1 and I2), and if the entry is valid, you will get your Branch
>>> Code, and then the following output:
>>> 1) a short list of close matches, and the estimated time-frame for the
>>> common ancestor of the very closest match;
>>> 2) a map showing the frequency of occurrence of your Branch Code in all
>>> countries/regions across Europe;
>>> 3) a list of SNP mutation pathways, with suggestions for your likely path
>>> based on your Branch Code.
>>> Finally, there is a link that discusses the simple methodology I used, and
>>> that link also gives additional details such as the computed tree showing
>>> the "big picture" view of how people in y-Haplogroups I1 and I2 are
>>> Eventually, I may add y-Haplogroups R1b and R1a.
>>> In the meantime, for I1 and I2 people, let me know how you go.
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