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Subject: Re: Mallory "single nucleotide polymorphism" DNA mutation
Date: 29 Mar 2006 06:31:25 -0700

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Classification: Query

Message Board URL:

http://boards.ancestry.com/mbexec/msg/rw/2Iy.2ACEB/729.1

Message Board Post:

Hi Gary,

I noticed that two of your "Northern" Mallorys have a null439, though the third one does not.

I would say the chances are less than 2% that the third Mallory shares a common ancestor with the two Mallorys with the "blue 12".

In general, if the FTDNA lab does not detect a marker value on the first pass, they'll repeat the test two more times. If they don't detect a value on all three passes, then they call the marker value a "null."

FTDNA has direct-seqeuenced the region around DYS439 on about 20 of the participants and have found a "single nucleotide polymorphism" (SNP) in every one.

Consequently, if they don't get a value in three attempts for a new participant, then it's a near-certainty that there's a SNP in the flanking region of DYS439

However, there's been one case out of fifty where the FTDNA lab assigned a value for DYS439 for a participant when they should have called it a null. That's where the 2% uncertainly comes in.

If the three Northern Mallorys have a strong paper trail back to a common ancestory, then it might be worthwhile asking FTDNA to verify that the third Northern Mallory does not have a null at DYS439 (they don't charge for such a re-check).

On the other hand, if your three Mallorys do not have a strong paper trail to the same ancestory, then given that the match is 11/12, and given the high amount of convergence with R1b1c, it's possible they just coincidently have similar values.

Best Regards, Leo

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