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Archiver > GENEALOGY-DNA > 2005-01 > 1105571328


From: Charles <>
Subject: Re: [DNA] Male Line Specific Y-STR Average Mutation Rates -- theone size shoe/(haplotype mutation rate) fits all approach is not valid,imo -- corrected URL link
Date: Wed, 12 Jan 2005 18:08:55 -0500
References: <014701c4f8f6$26e5e3a0$6401a8c0@whit>
In-Reply-To: <014701c4f8f6$26e5e3a0$6401a8c0@whit>


Whit,

What I am suggesting is that you change the baseline from Number of
Mutations to "Surname Projects Y-STR Haplotype Average Mutation Rate". I
did that below and left the right column the same.

If you have a hundred family lines (or subsets of a population), which
within those family line there is a unique average mutation rate do to
some mechanism in the Y chromosome which we don't yet understand, that
average higher or lower rate in that family line will carry over through
time and generations. Some family lines having a consistently higher
rate than others. Some having a consistently lower rate. Average all the
family line distinct rates together and you get an average rate of the
family rates which should be the same average rate as if we randomly
selected 1000 males at random from all the families and determined the
average mutation rate that way. The randomly selecting of a few thousand
male from the overall population type study was done via the father-son
pairs type experiment. What I am proposing is to get results from a few
hundred surname projects, plot a histogram, compute the average from
that, and see if it agrees with the random selected males rates commonly
quoted. It should, imo. But my project would clearly point out that
families have distinct average Y-STR haplotype mutation rates running
with their Y chromosome line.

We should end up with determining the same overall average mutation rate
as with randomly sample all males overall, but my project will try to
demonstrate that the average mutation rate is different for one male
line chromosome than for others.

Surname Project
Y-STR Haplotype
Average Mutation
Rate

Ave Mutation Rate No. of Projects
.0010.................. 1
.0015.................. 4
.0020.................. 9
.0025.................. 15
.0030.................. 18
.0035.................. 17
.0040.................. 14
.0045.................. 10
.0050.................. 6
.0055.................. 3
.0060................. 1

Hope this clarifies what I am trying to do with my new Log.

Charles Kerchner
http://www.kerchner.com/cgi-kerchner/ystrmutationrate.cgi
http://www.kerchner.com/dnamutationrates.htm

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