GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2007-02 > 1171551606


From: "Roberta J. Estes" <>
Subject: Re: [DNA] TMRCA
Date: Thu, 15 Feb 2007 10:00:06 -0500
In-Reply-To: <898755FF-A280-4139-AE30-4B26868F55B4@vizachero.com>


Actually, there is evidence that this is true, and further, that individual
families mutate at yet a different rate.

In the Estes project, there are two specific markers that are mutating at an
extremely high rate, one mutates at 500 times the expected rate and one at
250 times the expected rate.

Last fall at the Family Tree DNA conference, I did a presentation about
genealogy and DNA, and included in that presentation the information about
the genealogy of this line and the mutations and the rate I had calculated.
The reason I had included this, aside from the general interest factor, is
because I knew that the scientists from Univ. of Arizona would be present
and I wanted them to show my the error of my ways, or if my calculations
were off, or something. Failing that, I wanted to know if there is a
logical explanation for any of this.

Their answer to me was that there is nothing wrong with my calculations, and
yes, they are in fact mutating at a hugely higher rate than we would expect
to see generally. However, haplogroups and families do mutate at different
rates, and we don't know why or how this might be "controlled" yet. They
said they are just as interested in this as I am, but have no answers yet.

Roberta Estes

-----Original Message-----
From:
[mailto:] On Behalf Of Vincent Vizachero
Sent: Thursday, February 15, 2007 9:00 AM
To:
Subject: Re: [DNA] TMRCA


On Feb 15, 2007, at 6:42 AM, Elizabeth O'Donoghue wrote:

> Another issue I've seen commented on is that mutation rates can differ
> between haplogroups . . . .

I don't think there is any evidence that this is actually true.

Vince

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