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Archiver > GENEALOGY-DNA > 2007-02 > 1171573856


From: "Alister John Marsh" <>
Subject: Re: [DNA] TMRCA
Date: Fri, 16 Feb 2007 10:10:56 +1300
In-Reply-To: <898755FF-A280-4139-AE30-4B26868F55B4@vizachero.com>


Vince,

You said..

>>>>>>>
> Another issue I've seen commented on is that mutation rates can differ
> between haplogroups . . . .

I don't think there is any evidence that this is actually true.
<<<<<<<

There is a suggestion that longer alleles are more prone to mutate. Some
haplogroups have on average longer alleles at some markers, so on those
makers might be more prone to mutate. Depending on the marker set selected,
some haplogroups might have more tendencies to mutate on those markers.

Some time ago I was summing up all of the marker vales in a 37 marker set
for individuals. I don't recall the exact details, but as I recall, some
haplogroups had on average a higher sum of allele values, at least in the
sampling I took. I had considered summing the allele values for a selection
of different haplogroups at 67 markers. It would be interesting to see if
there is any significant difference. If some haplogroups had higher allele
sums, they might be more prone to mutations.

John.





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